Holiday Dilemmas

I went shopping today, but made no headway on the Christmas present front. I am old enough that I should probably buy gifts for everyone, but what the hell do you buy grandparents? A college age sister? My mother, who claims to want nothing? My family will contend to the last that they don't want anything in particular and then snark if I don't buy them something. I could make something crafty, but lack ideas. Help!